Description

H-Ala-His-Ala-Oh CAS NO 146321-25-7 is a synthetic tripeptide composed of alanine and histidine residues, serving as a crucial building block and research tool in peptide chemistry. Its defined sequence makes it valuable for studying enzyme-substrate interactions, peptide stability, and structure-activity relationships. This high-purity peptide is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and biochemical reagent sectors.

Application

• Pharmaceutical Research & Development: Used as a reference standard, an intermediate in the synthesis of more complex therapeutic peptides, and for studying proteolytic enzyme mechanisms.
• Biochemical Reagent: Functions as a substrate or inhibitor in enzymatic assays to study the specificity and kinetics of proteases like dipeptidyl peptidases.
• Peptide Synthesis: Acts as a key building block (segment) in solid-phase or solution-phase peptide synthesis for constructing longer, biologically active peptide chains.
• Nutritional Science Studies: Investigated for its potential role in metal ion chelation and antioxidant activity due to the presence of the histidine residue.
• Cosmetic Peptide Research: Explored as a potential intermediate for synthesizing peptides aimed at skin-conditioning and anti-aging applications.

Basic Information

Product Name	H-Ala-His-Ala-Oh
CAS No.	146321-25-7
Molecular Formula	C14H21N5O5
Molecular Weight	339.35 g/mol
Synonyms	Ala-His-Ala; L-Alanyl-L-histidyl-L-alanine; AHA; AH-OH; H-Ala-His-Ala-OH; Tripeptide AHA; 2-[(2-Aminopropanoyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]propanoic acid
EINECS	Contact for details

Quality Control

Every batch of H-Ala-His-Ala-Oh is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements for research and development. A Certificate of Analysis (COA) detailing specifications such as assay (HPLC), chiral purity, and residual solvent levels is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥97.0%
Chiral Purity	≥99.0% (L-isomer)
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines
Peptide Content	≥80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.