Description

Fmoc-L-Abu(3R-N3)-Oh CAS NO 146306-79-8 is a specialized, non-proteinogenic amino acid derivative featuring an azide functional group at the β-carbon position, protected by a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the site-specific incorporation of bioorthogonal handles for subsequent click chemistry modifications, such as Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). It is essential for researchers and manufacturers in pharmaceutical R&D and biotechnology who are developing peptide-based therapeutics, diagnostic probes, and bioconjugates that require precise labeling or functionalization.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary building block for the Fmoc-strategy synthesis of peptides containing azido-functionalized amino acids.
• Bioconjugation and Labeling: Enables site-specific "click" chemistry conjugation with alkyne-bearing fluorophores, biotin, polyethylene glycol (PEG), or drug molecules for creating targeted bioconjugates.
• Chemical Biology Probes: Used to synthesize activity-based probes (ABPs) or photoaffinity labels for studying protein function, interactions, and localization.
• Peptidomimetic Drug Discovery: Incorporation into peptide backbones to create novel structures with enhanced metabolic stability, bioavailability, or specific biological activity.
• Material Science: Serves as a monomer for creating functionalized polymers or surfaces with bioactive peptide sequences for tissue engineering or biosensor applications.
• Antibody-Drug Conjugate (ADC) Research: Facilitates the development of novel linkers and payload attachment strategies in ADC design.

Basic Information

Product Name	Fmoc-L-Abu(3R-N3)-Oh
CAS No.	146306-79-8
Molecular Formula	C₂₀H₂₀N₄O₄
Molecular Weight	380.40 g/mol
Synonyms	Fmoc-3-azido-L-homoalanine; Fmoc-L-3-azidohomoalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-azido-L-homoalanine; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-azidobutanoic acid; Fmoc-Aha(3-azido)-OH; Fmoc-L-β-azidohomoalanine; Fmoc-L-Abu(N3)-OH; N-α-Fmoc-3-azido-L-homoalanine
EINECS	Contact for details

Quality Control

Our Fmoc-L-Abu(3R-N3)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for peptide synthesis and bioconjugation research. Certificates of Analysis (COA) with detailed HPLC, NMR, and MS data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.