Description

5-Cyano-2-Fluorobenzaldehyde is a versatile and high-purity aromatic aldehyde building block, distinguished by its strategically positioned cyano and fluorine substituents. This compound is critical for synthesizing advanced pharmaceutical intermediates and agrochemicals, where its unique electronic properties enable precise molecular modifications. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex heterocyclic frameworks and active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials, such as fluorinated polymers and molecular semiconductors.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic & Industrial R&D: Utilized in research laboratories for method development and exploring new chemical entities in medicinal chemistry.

Basic Information

Product Name	5-Cyano-2-Fluorobenzaldehyde
CAS No.	146137-79-3
Molecular Formula	C8H4FNO
Molecular Weight	149.12 g/mol
Synonyms	2-Fluoro-5-formylbenzonitrile; 2-Fluoro-5-cyanobenzaldehyde; 5-Cyano-2-fluorobenzaldehyde; Benzonitrile, 2-fluoro-5-formyl-; 146137-79-3; 2-Fluoro-5-cyanobenzaldehyde; 5-Formyl-2-fluorobenzonitrile
EINECS	Contact for details

Quality Control

Our 5-Cyano-2-Fluorobenzaldehyde is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents, strong bases, and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.