Description

Margatoxin is a highly potent and selective peptide toxin originally isolated from the venom of the scorpion *Centruroides margaritatus*. This compound is a valuable biochemical tool for researchers, specifically functioning as a potent and selective blocker of voltage-gated potassium channels (Kv1.3). Its primary value lies in enabling critical studies in immunology and neuroscience, where it is used to investigate T-cell activation, autoimmune diseases, and neuronal signaling pathways. This product is essential for pharmaceutical R&D, academic research, and biotechnology applications focused on ion channel modulation.

Application

• Immunology Research: A key tool for studying Kv1.3 channels in effector memory T-cells, relevant to autoimmune diseases like multiple sclerosis, type I diabetes, and rheumatoid arthritis.
• Neuroscience Studies: Used to probe the role of potassium channels in neuronal excitability, synaptic transmission, and action potential propagation.
• Drug Discovery & Pharmacology: Serves as a reference standard and selectivity agent in high-throughput screening for novel immunomodulatory and neurological therapeutics.
• Cellular Physiology: Employed in patch-clamp electrophysiology and fluorescence-based assays to characterize ion channel function and inhibition.
• Biochemical Reagent: Used in the study of peptide-protein interactions and the structure-function relationships of ion channel blockers.

Basic Information

Product Name	Margatoxin
CAS No.	145808-47-5
Molecular Formula	C192H274N52O55S7
Molecular Weight	~4195.0 g/mol
Synonyms	MgTX; Margatoxin (scorpion toxin); ShK-like peptide 2; Potassium channel toxin α-KTx 2.2; Voltage-gated potassium channel subunit Kv1.3 blocker
EINECS	Contact for details

Quality Control

Our Margatoxin is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and biological activity. Each lot is subjected to comprehensive analytical testing, including HPLC for purity verification, mass spectrometry for identity confirmation, and functional bioassays to validate its potency as a Kv1.3 channel blocker. A detailed Certificate of Analysis (COA) documenting purity, concentration, and specific activity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the lyophilized powder under desiccant. Avoid repeated freeze-thaw cycles of reconstituted solutions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Biological Activity (IC50, Kv1.3)	≤ 1 nM
Endotoxin Level	< 1.0 EU/mg
Solubility	Soluble in water or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.