Description

(S)-n-Acetyl-L-Leucyl-n-(1-Formyl-3-Mercaptopropyl)-L-Leucinamide CAS NO 145757-50-2 is a specialized synthetic peptide derivative featuring a unique formyl and mercaptopropyl side chain. This compound is of significant interest in advanced pharmaceutical research and development, particularly for its potential as a building block in protease inhibitor design and as a precursor for novel bioconjugates. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and the synthesis of bioactive peptide analogs.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of novel protease inhibitors and enzyme-targeted therapeutics.
• Medicinal Chemistry Research: Used as a specialized building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Peptide-Based Drug Synthesis: Incorporated into the synthesis of complex peptide analogs and mimetics designed for enhanced stability and bioavailability.
• Bioconjugation & Probe Development: The reactive formyl and thiol groups enable its use in creating fluorescent probes, affinity labels, or drug-linker constructs for targeted delivery.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme mechanisms, particularly those involving cysteine or serine proteases.

Basic Information

Product Name	(S)-n-Acetyl-L-Leucyl-n-(1-Formyl-3-Mercaptopropyl)-L-Leucinamide
CAS No.	145757-50-2
Molecular Formula	C20H36N4O5S
Molecular Weight	444.59 g/mol
Synonyms	Ac-Leu-Leu-NH-CH(CH2SH)-CH2-CHO; N-Acetyl-L-leucyl-N-[1-formyl-3-mercaptopropyl]-L-leucinamide; (S)-N-Acetyl-L-leucyl-N-(1-formyl-3-mercaptopropyl)-L-leucinamide; Ac-LL-CHO-SH; Leu-Leu Peptidomimetic; Protease Inhibitor Intermediate; CAS 145757-50-2
EINECS	Contact for details

Quality Control

Our (S)-n-Acetyl-L-Leucyl-n-(1-Formyl-3-Mercaptopropyl)-L-Leucinamide is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing specific test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. For long-term storage, desiccants are recommended. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.