Description

8-[(4-Bromophenyl)Methyl]-5,8-Dihydro-2,4-Dimethylpyrido[2,3-D]Pyrimidin-7(6H)-One is a high-purity, advanced pharmaceutical intermediate belonging to the pyridopyrimidinone class of heterocyclic compounds. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs) and for use in medicinal chemistry research. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a core scaffold or a functionalized building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Chemical Biology Probes: Serves as a starting material for developing tool compounds and probes to study biological mechanisms and enzyme functions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.
• Academic Research: Utilized in university and institutional labs for advanced organic synthesis projects and the development of new synthetic methodologies.

Basic Information

Product Name	8-[(4-Bromophenyl)Methyl]-5,8-Dihydro-2,4-Dimethylpyrido[2,3-D]Pyrimidin-7(6H)-One
CAS No.	145733-62-6
Molecular Formula	C₁₇H₁₈BrN₃O
Molecular Weight	360.25 g/mol
Synonyms	5,8-Dihydro-2,4-dimethyl-8-[(4-bromophenyl)methyl]pyrido[2,3-d]pyrimidin-7(6H)-one; 8-(4-Bromobenzyl)-5,8-dihydro-2,4-dimethylpyrido[2,3-d]pyrimidin-7(6H)-one; Pyrido[2,3-d]pyrimidin-7(6H)-one, 8-[(4-bromophenyl)methyl]-5,8-dihydro-2,4-dimethyl-; CAS 145733-62-6
EINECS	Contact for details

Quality Control

Every batch of our 8-[(4-Bromophenyl)Methyl]-5,8-Dihydro-2,4-Dimethylpyrido[2,3-D]Pyrimidin-7(6H)-One is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements of pharmaceutical R&D and cGMP environments. Certificates of Analysis (COA) detailing specifications such as HPLC purity, NMR confirmation, and residual solvent levels are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.