Description

(Tyr69,Ala71,72,Lys74)-C3A (69-77) CAS NO 145702-79-0 is a synthetic peptide fragment derived from the complement component C3a, specifically engineered with specific amino acid substitutions. This modified sequence is a critical research tool for studying the structure-activity relationships, receptor binding, and signaling pathways of the C3a anaphylatoxin in the complement system. It is primarily utilized by researchers and developers in immunology, pharmacology, and biotechnology for investigating inflammatory processes, immune modulation, and developing novel therapeutic agents.

Application

• Biomedical Research: Fundamental studies on the complement system, C3a receptor (C3aR) activation, and downstream signaling cascades.
• Drug Discovery: Serving as a reference standard or a lead compound in the development of C3aR agonists or antagonists for treating inflammatory and autoimmune diseases.
• Immunology Assays: Used in in vitro and in vivo models to elucidate the role of C3a in allergic responses, sepsis, and ischemia-reperfusion injury.
• Structure-Activity Relationship (SAR) Studies: Investigating how specific amino acid modifications at positions 69, 71, 72, and 74 affect the peptide's biological potency and selectivity.
• Receptor Binding Studies: Competitive binding assays to characterize the affinity of the modified peptide for the C3a receptor compared to the native ligand.
• Quality Control Reference: Acting as a high-purity standard for the analysis and quantification of related peptide compounds in research and development settings.

Basic Information

Item	Detail
Product Name	(Tyr69,Ala71,72,Lys74)-C3A (69-77)
CAS No.	145702-79-0
Molecular Formula	C55H84N14O15
Molecular Weight	1157.3 g/mol
Synonyms	C3a (69-77) analog; Complement C3a (69-77) fragment, (Tyr69,Ala71,Ala72,Lys74)-; H-Tyr-Ser-His-Ala-Ala-Lys-Leu-Gly-Leu-OH (modified); C3a Receptor Ligand Analog; [Tyr69, Ala71,72, Lys74]-C3a (69-77); Synthetic C3a Anaphylatoxin Fragment; Complement Component 3a Peptide Fragment; Research Peptide C3a (69-77)
EINECS	Contact for details

Quality Control

Our (Tyr69,Ala71,72,Lys74)-C3A (69-77) is produced and controlled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing batch-specific results are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical composition
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.