Description

n-(2-Chloro-5-Fluoro-Pyrimidin-4-Yl)-Guanidine is a high-purity, functionalized pyrimidine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Building block for developing new herbicides, fungicides, and plant growth regulators.
• Chemical Research: Valuable reagent for medicinal chemistry programs and structure-activity relationship (SAR) studies.
• Custom Synthesis: Used by contract research and manufacturing organizations (CROs/CMOs) for client-specific projects.
• Material Science: Potential monomer or functional additive in the development of advanced polymers and functional materials.

Basic Information

Product Name	n-(2-Chloro-5-Fluoro-Pyrimidin-4-Yl)-Guanidine
CAS No.	145694-76-4
Molecular Formula	C5H4ClFN6
Molecular Weight	202.57 g/mol
Synonyms	2-Chloro-5-fluoro-N-(diaminomethylene)pyrimidin-4-amine; 4-Guanidino-2-chloro-5-fluoropyrimidine; Guanidine, N-(2-chloro-5-fluoro-4-pyrimidinyl)-; 2-Chloro-5-fluoropyrimidin-4-ylguanidine; (2-Chloro-5-fluoropyrimidin-4-yl)guanidine; 145694-76-4; 4-(2-Chloro-5-fluoropyrimidin-4-yl)guanidine
EINECS	Contact for details

Quality Control

Our n-(2-Chloro-5-Fluoro-Pyrimidin-4-Yl)-Guanidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.