Description

Hemoglobin Brescia is a specific, naturally occurring variant of human hemoglobin, identified by the CAS registry number 145686-64-2. This protein is of significant interest in biochemical and clinical research for studying the structure-function relationships of hemoglobinopathies and oxygen transport mechanisms. It serves as a critical reference material and reagent for scientists and manufacturers in the fields of hematology research, diagnostic assay development, and biopharmaceutical quality control.

Application

• Biochemical Research: Used as a model protein for studying oxygen-binding kinetics, protein stability, and the molecular pathology of hemoglobin variants.
• Diagnostic Manufacturing: Serves as a key component or calibrator in the production of in-vitro diagnostic (IVD) kits for hemoglobin analysis and blood disorder screening.
• Reference Standard: Acts as a high-purity certified reference material (CRM) for analytical method validation in clinical and research laboratories.
• Pharmaceutical Development: Utilized in biopharmaceutical R&D for studying protein-drug interactions and as a control in related analytical processes.
• Hematology Studies: Essential for investigating red blood cell physiology and the effects of specific mutations on hemoglobin function.
• Educational Purposes: Employed in advanced academic settings for teaching concepts in protein chemistry and molecular medicine.

Basic Information

Product Name	Hemoglobin Brescia
CAS No.	145686-64-2
Molecular Formula	C2952H4664N812O832S40Fe4 (Approximate for human hemoglobin tetramer)
Molecular Weight	~64,500 Da (for α2β2 tetramer)
Synonyms	Hb Brescia; Hemoglobin variant Brescia; HBB p.His92Tyr; β92 (F8) His→Tyr; Hemoglobin β-chain mutant Brescia; Unstable hemoglobin Brescia; Oxyhemoglobin Brescia; Deoxyhemoglobin Brescia
EINECS	Contact for details

Quality Control

Our Hemoglobin Brescia is produced and handled under stringent quality management protocols. Each batch is characterized using advanced analytical techniques to ensure identity, purity, and functional integrity. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications such as purity (by HPLC), spectral properties (UV-Vis), and functional oxygen-binding assays. We adhere to relevant guidelines for research-grade biological materials to ensure consistency and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. This product is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles. Aliquot contents upon first use to minimize degradation.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (UV-Vis)	Complies (Characteristic Soret band)
Purity (HPLC)	≥ 95% (Main peak)
Protein Content (Biuret/BCA)	≥ 90%
Methemoglobin Content	< 5%
Oxygen Affinity (P50)	Characteristic for variant
Solubility	Clear solution in buffer
Endotoxin	< 1.0 EU/mg (if specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.