Description

α-Cgrp (23-37) (Human) is a synthetic peptide fragment corresponding to amino acids 23-37 of the human Calcitonin Gene-Related Peptide (CGRP). This high-purity reference standard is critical for biochemical research, enabling precise study of CGRP receptor interactions and signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers focused on neuroscience, cardiovascular research, and migraine therapeutic development.

Application

• Biochemical Research: Used as a reference standard in receptor binding assays and functional studies to investigate the role of CGRP in pain transmission and vascular regulation.
• Pharmaceutical Development: Serves as a key tool in the screening and characterization of novel CGRP receptor antagonists for migraine and cardiovascular therapies.
• Diagnostic Assay Development: Employed in the calibration and validation of immunoassays (e.g., ELISA) designed to detect CGRP levels in biological samples.
• Neuroscience Studies: Facilitates research into the neurobiological mechanisms of CGRP, including its effects on sensory neurons and neurogenic inflammation.
• Academic & Institutional Research: Provides a defined, high-quality substrate for teaching and fundamental research in peptide chemistry and neuropeptide biology.

Basic Information

Product Name	α-Cgrp (23-37) (Human)
CAS No.	145459-33-2
Molecular Formula	C73H119N21O22S
Molecular Weight	1594.9 g/mol
Synonyms	Human α-CGRP (23-37); Calcitonin Gene-Related Peptide, α-(23-37)-peptide amide (human); α-CGRP Fragment 23-37; CGRP-I (23-37); h-α-CGRP23-37; Tyr-Lys-Met-Asn-Lys-Phe-Asn-Val-Phe-Ser-Val-Leu-Gly-NH2 (Disulfide bridge: Cys2-Cys7); α-Calcitonin Gene-Related Peptide (23-37) amide
EINECS	Contact for details

Quality Control

Every batch of α-Cgrp (23-37) (Human) is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data for purity (HPLC), peptide content, amino acid analysis, and mass spectrometry (MS) confirmation. Our quality commitment ensures the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by Mass Spectrometry
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Complies with theoretical composition
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.