Description

Kaliotoxin CAS NO 145199-73-1 is a potent and selective peptide neurotoxin originally isolated from the venom of the scorpion *Androctonus mauretanicus mauretanicus*. This compound is a valuable research tool for studying potassium (K⁺) channels, specifically blocking Kv1.1, Kv1.3, and certain calcium-activated potassium channels. It is essential for electrophysiology and neuropharmacology research, enabling scientists to investigate channel function, neuronal excitability, and related disease mechanisms. Target users include pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, ion channel drug discovery, and toxin-based probe development.

Application

• Neuroscience Research: As a selective blocker for voltage-gated potassium channels (Kv1.1, Kv1.3) to study neuronal signaling and excitability.
• Electrophysiology: A critical pharmacological tool in patch-clamp experiments to characterize potassium channel subtypes and their roles in cellular physiology.
• Drug Discovery & Development: Used in high-throughput screening (HTS) assays to identify and validate novel modulators of potassium channels for therapeutic applications.
• Biochemical Studies: Employed in binding assays and structure-activity relationship (SAR) studies to understand toxin-channel interactions.
• Academic & Pharmaceutical R&D: Fundamental research into channelopathies, autoimmune diseases, and neurological disorders where potassium channels are implicated.
• Probe Development: Serves as a molecular template for developing labeled derivatives (e.g., fluorescent conjugates) for imaging and diagnostic applications.

Basic Information

Product Name	Kaliotoxin
CAS No.	145199-73-1
Molecular Formula	C164H256N50O47S6
Molecular Weight	~ 3820.5 g/mol
Synonyms	Kaliotoxin 1; KTX; α-KTx3.1; Potassium channel toxin α-KTx 3.1; Toxin KTX; Androctonus mauretanicus toxin; Scorpion toxin Kaliotoxin; ShK-like toxin 1
EINECS	Contact for details

Quality Control

Our Kaliotoxin is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and high biological activity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment, mass spectrometry (MS) for identity confirmation, and functional activity verification via electrophysiological or binding assays. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, concentration, and biological activity data.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted to avoid repeated freeze-thaw cycles and stored at -80°C. The product is hygroscopic (moisture-sensitive); ensure the container is sealed under anhydrous conditions after each use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Biological Activity (IC₅₀)	Specified per batch (typically nM range vs. Kv1.3)
Endotoxin Level	< 1.0 EU/μg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.