Description

H-Tyr-Pro-NH2 HCl is a high-purity, synthetic dipeptide derivative, specifically the C-terminal amide of the Tyr-Pro sequence. This compound is a valuable building block in peptide synthesis and pharmaceutical research, offering a protected tyrosine residue with a proline amide terminus. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise, high-quality intermediates for drug discovery and development programs. The product is supplied as a hydrochloride salt to enhance its stability and solubility profile.

Application

• Pharmaceutical Intermediate: Serves as a critical building block for the synthesis of more complex therapeutic peptides and peptidomimetics.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving proteases or kinases that recognize tyrosine-proline motifs.
• Drug Discovery: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and the development of novel bioactive compounds.
• Peptide Library Construction: A key component in the solid-phase or solution-phase synthesis of diverse peptide libraries for screening purposes.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	H-Tyr-Pro-NH2 HCl
CAS No.	145118-98-5
Molecular Formula	C14H20N3O3·HCl
Molecular Weight	315.79 g/mol
Synonyms	L-Tyrosyl-L-prolinamide hydrochloride; Tyr-Pro-NH2·HCl; H-Tyr-Pro-NH2·HCl; Tyrosine-Proline amide hydrochloride; N-(2-Amino-2-oxoethyl)-L-tyrosyl-L-prolinamide hydrochloride; TYR-PRO-NH2 HCL; L-Tyrosine, L-prolylamide, hydrochloride (1:1); 145118-98-5
EINECS	Contact for details

Quality Control

Our H-Tyr-Pro-NH2 HCl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates. Specifications are designed to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay (Titration)	97.0% - 103.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.