Description

3-Fluoro-4-Methylbenzyl Bromide is a versatile and high-purity organobromide building block essential for advanced organic synthesis. Its molecular structure, featuring both a reactive benzyl bromide group and a fluorine substituent, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity, stability, and selectivity.
• Liquid Crystal & OLED Material Production: Serves as a building block for fluorinated liquid crystal molecules and organic light-emitting diode (OLED) materials, improving electronic properties and device performance.
• Cross-Coupling Reactions: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to introduce the 3-fluoro-4-methylbenzyl moiety into more complex aromatic systems.
• Ligand & Catalyst Development: Useful for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and fine chemical manufacturing.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D exploring new fluorination methodologies and the structure-activity relationships of benzyl halides.

Basic Information

Product Name	3-Fluoro-4-Methylbenzyl Bromide
CAS No.	145075-44-1
Molecular Formula	C8H8BrF
Molecular Weight	203.05 g/mol
Synonyms	1-(Bromomethyl)-3-fluoro-4-methylbenzene; (3-Fluoro-4-methylphenyl)methyl Bromide; 4-Methyl-3-fluorobenzyl Bromide; α-Bromo-3-fluoro-4-methyltoluene; 3-Fluoro-p-tolylmethyl Bromide; 3-Fluoro-4-methylbenzylbromide; 3-Fluoro-4-methyl-benzylbromide
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-4-Methylbenzyl Bromide is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids, organic solvents, fluorides, and strong alkalis. The container must be kept tightly closed in a dry and inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.