Description

Fmoc-L-Glutamic Acid γ-Methyl Ester is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity building blocks to construct complex peptides and peptidomimetics with precision. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for drug discovery, development of therapeutic peptides, and biochemical studies.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected building block for the sequential assembly of peptide chains.
• Pharmaceutical Intermediates: Used in the research and production of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation: Serves as a precursor for introducing glutamic acid residues with a protected side chain for linker or labeling chemistry.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify novel bioactive compounds.
• Academic & Industrial Research: Fundamental reagent for studying protein structure-function relationships and developing new synthetic methodologies.
• Production of Glutamate-Containing Peptides: Specifically incorporated to introduce glutamic acid while protecting the γ-carboxyl group during synthesis.

Basic Information

Product Name	Fmoc-L-Glutamic Acid γ-Methyl Ester
CAS No.	145038-50-2
Molecular Formula	C₂₁H₂₁NO₆
Molecular Weight	383.40 g/mol
Synonyms	Fmoc-Glu(OMe)-OH; N-(9-Fluorenylmethoxycarbonyl)-L-glutamic acid 5-methyl ester; Fmoc-L-Glu(OMe)-OH; (S)-5-Methoxy-5-oxo-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)pentanoic acid; N-α-Fmoc-L-glutamic acid γ-methyl ester; Fmoc-Glutamic acid γ-methyl ester; Fmoc-Glu-OMe; N-Fmoc-L-glutamic acid 1-methyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-L-Glutamic Acid γ-Methyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive applications like peptide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices and can provide material meeting specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.