Description

Fmoc-Dl-Nle-Oh CAS NO 144701-20-2 is a protected amino acid derivative, specifically the Fmoc (9-fluorenylmethoxycarbonyl) derivative of norleucine (Nle), a non-natural amino acid analog. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and peptidomimetics. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research focused on creating novel therapeutic peptides, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent for the automated, stepwise construction of custom peptide sequences.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including hormone analogs, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation and Probe Development: Serves as a modified amino acid for introducing specific functional groups or labels into peptides for imaging or targeting studies.
• Structural Biology Studies: Incorporation of norleucine, an isosteric analog of methionine, aids in protein structure-function analysis and stability studies.
• Combinatorial Chemistry Libraries: A key component for generating diverse peptide libraries for high-throughput screening in drug discovery.
• Academic and Contract Research: A staple reagent in university and CRO laboratories for fundamental peptide chemistry and custom synthesis projects.

Basic Information

Product Name	Fmoc-Dl-Nle-Oh
CAS No.	144701-20-2
Molecular Formula	C₂₁H₂₃NO₄
Molecular Weight	353.41 g/mol
Synonyms	Fmoc-Norleucine-OH; Fmoc-DL-2-Aminohexanoic Acid; N-(9-Fluorenylmethoxycarbonyl)-DL-norleucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-DL-norleucine; Fmoc-DL-Nle-OH; DL-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]hexanoic acid; Fmoc-DL-homoalanine
EINECS	Contact for details

Quality Control

Our Fmoc-Dl-Nle-Oh is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with customer requirements for specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.