Description

α-Dendrotoxin is a highly selective and potent polypeptide neurotoxin isolated from the venom of the Eastern green mamba (*Dendroaspis angusticeps*). This compound is a critical research tool for the study of voltage-gated potassium (Kv) channels, particularly the Kv1.1, Kv1.2, and Kv1.6 subtypes, due to its ability to block these channels with high affinity. It is essential for neuroscientists, pharmacologists, and toxicologists engaged in fundamental neurological research, drug discovery for channelopathies, and the development of novel therapeutic agents.

Application

• Neuroscience Research: Primary tool for electrophysiological studies to characterize and inhibit specific subtypes of voltage-gated potassium channels in neuronal tissues.
• Pharmacology & Drug Discovery: Used in high-throughput screening assays to identify and evaluate new compounds that modulate potassium channel activity for potential therapeutic use.
• Toxicology Studies: Serves as a reference toxin for understanding the mechanism of action of snake venoms and for developing antivenoms.
• Biochemical Assay Development: Employed in the development of binding assays (e.g., radio-ligand binding, fluorescence polarization) to study receptor-ligand interactions.
• Academic & Institutional Research: Fundamental reagent for university and government labs investigating synaptic transmission, neuronal excitability, and neurological disorders like epilepsy and multiple sclerosis.
• Diagnostic Tool Manufacturing: Potential use as a component in specialized diagnostic kits for research into autoimmune and channelopathy diseases.

Basic Information

Product Name	α-Dendrotoxin
CAS No.	144637-68-3
Molecular Formula	C184H281N55O53S7
Molecular Weight	~4230.8 g/mol
Synonyms	Dendrotoxin I; DTX-I; DTX; Toxin I (Dendroaspis angusticeps); α-Dendrotoxin; Dendrotoxin K; Potassium channel toxin α-DTx; ShK-like toxin; UNII-5W6S70C2UW
EINECS	Contact for details

Quality Control

Our α-Dendrotoxin is produced and handled under stringent conditions to ensure the highest standards of purity and biological activity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, potency, and sterility. Our quality systems are designed to meet the rigorous demands of GLP (Good Laboratory Practice) and research-grade standards, ensuring traceability and consistency for critical scientific work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot into working solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Potency (Biological Assay)	≥ 98% (vs. reference standard)
Endotoxin Level (LAL)	< 1.0 EU/µg
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.