Description

Ac-Cys(Farnesyl)-Val-Ile-Met-Oh is a specialized, chemically modified peptide featuring a farnesyl thioether linkage on a cysteine residue. This compound is of significant interest in biochemical and pharmaceutical research, particularly for studying protein prenylation, a critical post-translational modification involved in membrane association and signal transduction. It serves as a valuable tool compound or synthetic intermediate for researchers in drug discovery, proteomics, and enzymology, enabling the investigation of cancer pathways, neurodegenerative diseases, and other biological processes regulated by prenylated proteins.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic assays to study protein farnesyltransferases (FTase) and related enzymes.
• Drug Discovery: Serves as a key intermediate or reference standard in the development of therapeutics targeting prenylation-dependent pathways, such as in oncology.
• Proteomics Studies: Employed to investigate the role of protein prenylation in cellular localization, protein-protein interactions, and signal transduction mechanisms.
• Enzyme Mechanism Analysis: Utilized as a tool to elucidate the kinetics and specificity of prenyltransferase enzymes.
• Synthetic Biology: Acts as a building block for the chemical synthesis of more complex, modified peptides or protein mimics for functional studies.
• Academic & Institutional Research: Provides a critical reagent for universities and research institutes focusing on cell biology, molecular biology, and medicinal chemistry.

Basic Information

Product Name	Ac-Cys(Farnesyl)-Val-Ile-Met-Oh
CAS No.	144608-65-1
Molecular Formula	C35H59N5O6S2
Molecular Weight	709.99 g/mol
Synonyms	N-Acetyl-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteinyl-L-valyl-L-isoleucyl-L-methionine; Acetyl-Cys(Farnesyl)-Val-Ile-Met-OH; Farnesylated Peptide Ac-CVIM; N-Acetyl-S-farnesyl-L-cysteinyl-L-valyl-L-isoleucyl-L-methionine; S-Farnesyl-N-acetyl-L-cysteinyl-L-valyl-L-isoleucyl-L-methionine; FTase Substrate Peptide Analog; Prenylated Tetrapeptide; CAS 144608-65-1
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as purity (HPLC), identity (MS, NMR), and peptide content. We adhere to strict quality management protocols suitable for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive) and easily oxidized (store under inert atmosphere). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.