Description

Paliperidone CAS NO 144598-75-4 is an atypical antipsychotic pharmaceutical active ingredient, chemically known as 9-Hydroxyrisperidone. It is a critical intermediate and the active metabolite of risperidone, offering a distinct therapeutic profile for the treatment of schizophrenia and schizoaffective disorder. This high-purity compound is essential for pharmaceutical manufacturers and research institutions developing controlled-release formulations and conducting advanced neuropharmacological studies.

Application

• Pharmaceutical API: Primary active ingredient in extended-release tablet formulations for the treatment of schizophrenia.
• Neuropharmacology Research: Key reference standard in studies investigating dopamine D2 and serotonin 5-HT2A receptor antagonism.
• Generic Drug Development: Critical component for companies developing bioequivalent versions of branded paliperidone medications.
• Metabolite Studies: Used as an analytical standard for quantifying risperidone metabolism in pharmacokinetic and bioequivalence testing.
• Formulation R&D: Employed in the development of novel drug delivery systems, including injectable sustained-release suspensions.
• Quality Control Laboratories: Serves as a primary standard for HPLC and other analytical methods to ensure drug product purity and potency.

Basic Information

Product Name	Paliperidone
CAS No.	144598-75-4
Molecular Formula	C23H27FN4O3
Molecular Weight	426.48 g/mol
Synonyms	9-Hydroxyrisperidone; Invega (Trade Name); 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one; R076477; Paliperidone Base
EINECS	Contact for details

Quality Control

Our Paliperidone is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling via HPLC, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) are provided, detailing compliance with relevant internal specifications and supporting its use as a pharmaceutical intermediate or reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.