Description

1-Bromo-3-Chloro-2-Fluorobenzene is a high-purity, multi-halogenated aromatic building block essential for advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily sought by R&D chemists and process development scientists working on active ingredients, functional materials, and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the halogen pattern confers specific biological activity.
• Material Science: Serves as a precursor for liquid crystals, organic semiconductors, and other functional fluorinated materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions due to the reactive bromo and chloro groups.
• Chemical Research: Employed in academic and industrial labs for method development and exploring new reaction pathways in organofluorine chemistry.
• Dye and Pigment Intermediate: Used in the synthesis of specialized halogenated dyes and pigments.

Basic Information

Product Name	1-Bromo-3-Chloro-2-Fluorobenzene
CAS No.	144584-65-6
Molecular Formula	C6H3BrClF
Molecular Weight	209.44 g/mol
Synonyms	2-Bromo-6-Chloro-1-Fluorobenzene; 3-Chloro-2-Fluorobromobenzene; 1-Bromo-3-chloro-2-fluorobenzol; 2-Fluoro-3-chlorobromobenzene; Benzene, 1-bromo-3-chloro-2-fluoro-; 144584-65-6; 2-Fluoro-6-chlorobromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-Chloro-2-Fluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support compliance with global regulatory frameworks, including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 2°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.