Description

Tirofiban is a highly potent, non-peptide glycoprotein IIb/IIIa receptor antagonist, a critical active pharmaceutical ingredient (API) in the treatment of acute coronary syndromes. Its primary value lies in its ability to prevent platelet aggregation, thereby reducing the risk of thrombotic complications during percutaneous coronary interventions. This compound is essential for pharmaceutical manufacturers developing antiplatelet and antithrombotic injectable formulations. Tirofiban CAS NO 144494-65-5 is a key therapeutic agent in modern cardiology.

Application

• Primary Active Pharmaceutical Ingredient (API) in the manufacture of injectable antiplatelet drugs.
• Critical component in formulations for the treatment of unstable angina and non-Q-wave myocardial infarction.
• Used in combination with heparin and aspirin for the management of acute coronary syndromes.
• Essential in clinical research and development of next-generation antithrombotic therapies.
• Key material for compounding pharmacies and sterile injectable production facilities.
• Reference standard for analytical testing and quality control in pharmaceutical laboratories.

Basic Information

Product Name	Tirofiban
CAS No.	144494-65-5
Molecular Formula	C22H36N2O5S
Molecular Weight	440.60 g/mol
Synonyms	Tirofiban Hydrochloride; Aggrastat; MK-383; L-700,462; N-(Butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine; (2S)-2-[[(Butylsulfonyl)amino]methyl]-3-(4-hydroxyphenyl)propanoic acid; Tyrosine, N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-
EINECS	Contact for details

Quality Control

Our Tirofiban is manufactured under strict quality management systems, targeting compliance with ICH Q7 guidelines for Active Pharmaceutical Ingredients. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via validated methods. A Certificate of Analysis (COA) detailing results for appearance, assay (HPLC), related substances, residual solvents, and microbiological quality is provided with every shipment to ensure traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Microbiological Enumeration	Meets Ph. Eur. 2.6.12 / USP <61> requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.