Description

Fmoc-Gln(Mtt)-Oh is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is specifically designed to provide orthogonal protection for the glutamine side chain, enabling the synthesis of complex peptides with high fidelity. It is a critical building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing peptide-based therapeutics and diagnostic tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, allowing for the sequential assembly of peptide chains.
• Peptide Drug Development: Used in the research and production of therapeutic peptides, including hormones, antibiotics, and enzyme inhibitors.
• Combinatorial Chemistry: Serves as a building block in the generation of peptide libraries for drug discovery and screening.
• Bioconjugation: Facilitates the site-specific modification of peptides and proteins for creating antibody-drug conjugates (ADCs) or diagnostic probes.
• Academic & Industrial Research: A fundamental reagent for studying protein structure-function relationships and developing novel biomaterials.
• Custom Peptide Services: A standard offering from CROs and CDMOs providing bespoke peptide synthesis for clients worldwide.

Basic Information

Product Name	Fmoc-Gln(Mtt)-Oh
CAS No.	144317-23-7
Molecular Formula	C41H38N2O6
Molecular Weight	654.75 g/mol
Synonyms	Fmoc-Gln(Mtt)-OH; N-α-Fmoc-N-γ-Mtt-L-glutamine; Fmoc-L-glutamine(Mtt)-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-5-((4-methylphenyl)diphenylmethoxy)-5-oxopentanoic acid; Fmoc-Glutamine(Mtt)-OH; Fmoc-Gln(Mtt)-OH CAS 144317-23-7; Nα-Fmoc-Nγ-Mtt-L-glutamine; Fmoc-Gln(Mtt)
EINECS	Contact for details

Quality Control

Our Fmoc-Gln(Mtt)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to verify identity, purity, and absence of critical impurities. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and performance. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -18.0° (c=1, DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.