Description

H-Asn(Mtt)-OH is a protected amino acid derivative, specifically asparagine with its side chain amide protected by the 4-methyltrityl (Mtt) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and proteins. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential addition of asparagine residues during automated or manual peptide assembly.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including hormones, antibiotics, and targeted therapeutics.
• Bioconjugation and Protein Engineering: Serves as a precursor for introducing specific functional groups or labels into peptides and proteins.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening and drug discovery.
• Academic and Industrial Research: A fundamental reagent for studying protein structure-function relationships, enzyme substrates, and receptor ligands.
• Production of Custom Peptides: Used by CROs and CDMOs for the reliable and scalable manufacture of bespoke peptides for clients.

Basic Information

Item	Detail
Product Name	H-Asn(Mtt)-OH
CAS No.	144317-20-4
Molecular Formula	C25H25N3O3
Molecular Weight	415.49 g/mol
Synonyms	Fmoc-Asn(Mtt)-OH; N-α-Fmoc-N-γ-(4-methyltrityl)-L-asparagine; L-Asparagine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N4-(4-methylphenyl)diphenylmethyl]-; N-α-(9-Fluorenylmethoxycarbonyl)-N-γ-(4-methyltrityl)-L-asparagine; Fmoc-Asn(Mtt)-OH; Fmoc-L-Asn(Mtt)-OH; Asn(Mtt)-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-((bis(4-methylphenyl)(phenyl)methoxy)amino)-3-oxopropanoic acid
EINECS	Contact for details

Quality Control

Our H-Asn(Mtt)-OH is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.