Description

4-Bromo-2,3-Difluorophenol is a halogenated fluorophenol derivative that serves as a versatile and critical building block in advanced organic synthesis. Its unique structure, featuring bromine and fluorine substituents on the phenolic ring, makes it a valuable intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorine-containing drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and pesticides, where the difluorophenol moiety can enhance biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of specialty chemicals for electronic displays, leveraging its halogenated aromatic structure.
• Polymer Modification: Acts as a monomer or functionalization agent in the production of high-performance polymers and resins.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating novel chemical entities.

Basic Information

Product Name	4-Bromo-2,3-Difluorophenol
CAS No.	144292-32-0
Molecular Formula	C6H3BrF2O
Molecular Weight	208.99 g/mol
Synonyms	2,3-Difluoro-4-bromophenol; 4-Bromo-2,3-difluorophenol; Phenol, 4-bromo-2,3-difluoro-; 4-Brom-2,3-difluorophenol (German); 4-ブロモ-2,3-ジフルオロフェノール (Japanese)
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,3-Difluorophenol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to verify identity, potency, and impurity profiles. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support compliance with global regulatory frameworks, and our quality systems are designed to meet the stringent requirements of cGMP for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.