Description

(Gln18)-Pf4 (15-22) (Human) is a synthetic peptide fragment corresponding to a specific sequence of the human Platelet Factor 4 protein. This high-purity reference standard is critical for advanced biochemical research and assay development, ensuring precise and reproducible experimental results. It is primarily utilized by researchers and developers in the fields of hematology, thrombosis research, and immunology for studying platelet function, angiogenesis, and related inflammatory pathways.

Application

• Biochemical Research: Used as a reference standard in studies investigating the structure, function, and signaling mechanisms of Platelet Factor 4 (PF4).
• Assay Development & Validation: Serves as a critical calibrant and control material in the development of immunoassays (e.g., ELISA) and other analytical methods for PF4 detection.
• Heparin-Induced Thrombocytopenia (HIT) Research: Essential for in vitro studies modeling HIT, a serious immune-mediated complication of heparin therapy.
• Angiogenesis Studies: Applied in research exploring the role of PF4 and its fragments in regulating blood vessel formation.
• Peptide-Protein Interaction Analysis: Utilized in binding studies to map interaction sites with heparin, other glycosaminoglycans, or cellular receptors.
• Quality Control in Pharmaceutical Development: Acts as a system suitability standard in the QC testing of related biopharmaceutical products.

Basic Information

Product Name	(Gln18)-Pf4 (15-22) (Human)
CAS No.	144207-60-3
Molecular Formula	C38H64N12O13
Molecular Weight	896.99 g/mol
Synonyms	PF4 (15-22) (Human) fragment; Platelet Factor 4 (15-22) peptide; L-glutamine(18)-PF4 (15-22); CXCL4 (15-22); Chemokine (C-X-C motif) ligand 4 (15-22); PF-4 (15-22); (Gln18)-Platelet Factor 4 (15-22); Synthetic PF4 peptide fragment
EINECS	Contact for details

Quality Control

Every batch of (Gln18)-Pf4 (15-22) (Human) is manufactured and analyzed under stringent quality systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting standards for research-grade peptides. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and content is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the lyophilized powder at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent moisture absorption. Reconstituted solutions should be aliquoted and stored at -20°C or -80°C for stability.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Conforms to theoretical composition
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.