Description

Fmoc-Asp-Oall CAS NO 144120-53-6 is a protected aspartic acid derivative, specifically the allyl ester of N-(9-fluorenylmethoxycarbonyl)-L-aspartic acid, which is a critical building block in solid-phase peptide synthesis (SPPS). This compound matters because it provides orthogonal protection for the side-chain carboxylic acid group of aspartic acid, allowing for precise, sequential peptide chain assembly without unwanted side reactions. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, peptidomimetics, and complex organic molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid derivative for the controlled incorporation of aspartic acid into peptide sequences.
• Pharmaceutical Research: For the synthesis of peptide-based drug candidates, including hormones, enzyme inhibitors, and antiviral agents.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive compounds.
• Bioconjugation: Serves as a linker or intermediate in the preparation of peptide-protein or peptide-small molecule conjugates.
• Academic Research: A fundamental reagent in university and institutional labs studying peptide structure, function, and synthesis methodologies.
• Process Development: For scaling up the production of specific peptide sequences in pilot plants and manufacturing facilities.

Basic Information

Product Name	Fmoc-Asp-Oall
CAS No.	144120-53-6
Molecular Formula	C22H21NO6
Molecular Weight	395.41 g/mol
Synonyms	Fmoc-L-aspartic acid β-allyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartic acid 4-allyl ester; Fmoc-Asp(OAll)-OH; Fmoc-Asp(Allyl)-OH; Fmoc-L-Asp(OAll)-OH; N-Fmoc-L-aspartic acid β-allyl ester; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]butanedioic acid 4-allyl ester; Allyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-aspartate
EINECS	Contact for details

Quality Control

Our Fmoc-Asp-Oall is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material tailored to specific research or cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to maintain stability and prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.