Description

Bradykinin, Hyp(3)-Thi(5)-Tic(7)-Oic(8)-Desarg(9)- is a potent, modified peptide antagonist of the bradykinin B1 receptor. This compound is of significant value for research into inflammatory pathways, pain signaling, and vascular physiology. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel therapeutics for conditions like chronic pain, inflammation, and sepsis.

Application

• Pharmacological Research: Used as a selective B1 receptor antagonist to study receptor function, signal transduction, and downstream effects in cellular and animal models.
• Inflammation & Pain Studies: A critical tool for investigating the role of the kinin system in inflammatory diseases, neuropathic pain, and migraine.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the screening and development of new anti-inflammatory and analgesic agents.
• Cardiovascular Research: Employed to explore bradykinin's effects on blood pressure regulation, vascular permeability, and endothelial function.
• Biochemical Assay Development: Used as a high-purity ligand in competitive binding assays (e.g., radioligand binding) and functional assays to characterize new compounds.
• Academic & Clinical Research: Supports basic science investigations into peptide-receptor interactions and their pathophysiological implications.

Basic Information

Product Name	Bradykinin, Hyp(3)-Thi(5)-Tic(7)-Oic(8)-Desarg(9)-
CAS No.	144006-47-3
Molecular Formula	C50H68N14O11S2
Molecular Weight	1081.3 g/mol
Synonyms	B-9430; B9430; [Hyp3,Thi5,D-Tic7,Oic8]-Des-Arg9-Bradykinin; B1 Bradykinin Receptor Antagonist B-9430; Lys-Lys-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic; HOE-140 analogue; Des-Arg9-[Hyp3,Thi5,D-Tic7,Oic8]BK
EINECS	Contact for details

Quality Control

Our Bradykinin, Hyp(3)-Thi(5)-Tic(7)-Oic(8)-Desarg(9)- is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and content. We adhere to relevant standards for research-grade peptides, ensuring reliable performance in sensitive assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95%
Assay (Content)	≥ 90% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.