Description

(H-D-Cys-Ome)2 2 Hcl is a deuterated, protected derivative of the amino acid L-cysteine, specifically the dihydrochloride salt of the bis(methyl ester) dimer. This compound is a critical building block in advanced pharmaceutical research, particularly for the development of deuterated drugs where enhanced metabolic stability is required. It serves as a key chiral intermediate for peptide synthesis and medicinal chemistry applications in the pharmaceutical and biotechnology sectors.

Application

• Deuterated Drug Development: As a deuterium-labeled precursor for creating Active Pharmaceutical Ingredients (APIs) with improved pharmacokinetic profiles.
• Peptide Synthesis: Used as a protected, deuterated cysteine derivative in solid-phase and solution-phase peptide synthesis.
• Medicinal Chemistry Research: A crucial intermediate for structure-activity relationship (SAR) studies and the synthesis of novel therapeutic candidates.
• Isotope Labeling: Employed in the preparation of isotopically labeled compounds for use as internal standards in mass spectrometry (LC-MS/MS) for bioanalytical studies.
• Bioconjugation: Potential use in creating stable, labeled linkers for antibody-drug conjugates (ADCs) and other bioconjugation strategies.

Basic Information

Product Name	(H-D-Cys-Ome)2 2 Hcl
CAS No.	144000-36-2
Molecular Formula	C8H18D2Cl2N2O4S2
Molecular Weight	365.37 g/mol
Synonyms	Bis(L-cysteine methyl ester) dihydrochloride, deuterated; Deuterated Cystine dimethyl ester dihydrochloride; D2-Cys(OMe)-Cys(OMe)•2HCl; (2S,2'S)-2,2'-(Dithiobis(methylene))bis(2-amino-3,3-d2-3-hydroxypropanoate) dimethyl ester dihydrochloride; L-Cystine bis(methyl ester) dihydrochloride-d2; (S,S)-Cystine dimethyl ester-3,3'-d2 dihydrochloride
EINECS	Contact for details

Quality Control

Our (H-D-Cys-Ome)2 2 Hcl is manufactured under strict quality systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and isotopic enrichment, NMR for structural confirmation, and chiral analysis to ensure stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry standards for research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D)	≥ 98 atom % D
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.