Description

n-Acetyl-S-Farnesyl-Cysteinyl-Valyl-Isoleucyl-Serine is a synthetic, modified pentapeptide featuring a lipophilic farnesyl group and an N-terminal acetyl cap. This specialized molecular architecture is designed for advanced biochemical research, particularly in the study of protein prenylation, intracellular signaling pathways, and membrane-associated protein functions. It serves as a critical tool compound for pharmaceutical R&D, academic research in cell biology, and the development of targeted therapeutic agents.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic assays to study protein farnesyltransferase (FTase) activity and specificity.
• Signal Transduction Studies: Investigates the role of prenylated peptides in Ras and other small GTPase signaling cascades critical in cell proliferation and differentiation.
• Drug Discovery & Development: Serves as a reference standard, lead compound, or intermediate in the development of novel cancer therapeutics targeting aberrant prenylation pathways.
• Cell Biology: Employed in cellular uptake studies and localization experiments to understand membrane targeting and anchoring mechanisms of modified peptides.
• Proteomics & Peptide Chemistry: Acts as a model compound for developing analytical methods (HPLC, MS) for complex, lipidated peptides.

Basic Information

Product Name	n-Acetyl-S-Farnesyl-Cysteinyl-Valyl-Isoleucyl-Serine
CAS No.	143984-08-1
Molecular Formula	C38H64N6O7S
Molecular Weight	749.0 g/mol (approximately)
Synonyms	Acetyl-Farnesyl-Cys-Val-Ile-Ser-OH; N-Acetyl-S-trans,trans-Farnesyl-L-cysteinyl-L-valyl-L-isoleucyl-L-serine; Farnesylated Pentapeptide; FTase Substrate Peptide; Prenylated Peptide; Ac-Farnesyl-CVIS-OH; L-Serine, N-acetyl-L-cysteinyl-L-valyl-L-isoleucyl-, S-(3,7,11-trimethyl-2,6,10-dodecatrienyl) ester
EINECS	Contact for details

Quality Control

Our n-Acetyl-S-Farnesyl-Cysteinyl-Valyl-Isoleucyl-Serine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous analytical standards utilizing techniques such as HPLC, MS, and NMR for full characterization, ensuring the material meets the exacting requirements of pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.