Description

Fmoc-Arg(Boc)2-Oh is a high-purity, orthogonally protected derivative of the amino acid L-arginine, specifically designed for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over peptide chain assembly, particularly for sequences containing arginine residues. It is an essential building block for the pharmaceutical, biotechnology, and life sciences industries, enabling the synthesis of complex peptides for therapeutic, diagnostic, and research applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid derivative for the automated synthesis of peptide chains.
• Pharmaceutical Intermediates: Used in the research and development of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation and Labeling: Serves as a precursor for introducing arginine residues into modified peptides, proteins, or other biomolecules.
• Combinatorial Chemistry Libraries: A valuable reagent for generating diverse peptide libraries for high-throughput screening in drug discovery.
• Biochemical Research: Employed in academic and industrial laboratories for studying protein-protein interactions, enzyme substrates, and signal transduction pathways.
• Production of Custom Peptides: Essential for contract research and manufacturing organizations (CROs/CMOs) producing bespoke peptides for clients.

Basic Information

Product Name	Fmoc-Arg(Boc)2-Oh
CAS No.	143824-77-5
Molecular Formula	C32H43N5O8
Molecular Weight	625.72 g/mol
Synonyms	Fmoc-L-arginine(Boc)2-OH; Nα-Fmoc-Nω,Nω'-bis(tert-butoxycarbonyl)-L-arginine; Nα-(9-Fluorenylmethoxycarbonyl)-Nω,Nω'-bis(tert-butoxycarbonyl)-L-arginine; Fmoc-Arg(Boc2)-OH; Fmoc-Arg(Boc)-OH (Bis-Boc); (2S)-5-[[(2-Methylpropan-2-yl)oxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid; Fmoc-Arg(Boc)2; Fmoc-Arg(Pbf)-OH alternative (common related protecting group)
EINECS	Contact for details

Quality Control

Our Fmoc-Arg(Boc)2-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive peptide synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric integrity. Certificates of Analysis (COA) detailing specific results for identity, assay, purity, and related substances are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Specific Rotation	-10.0° to -14.0° (c=1 in DMF)
Purity (HPLC)	≥98.5%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.