Description

Enkephalinamide, Ala(2,5)- CAS NO 143791-43-9 is a synthetic peptide analog of the endogenous opioid peptide enkephalin, specifically modified with alanine substitutions at positions 2 and 5. This compound is of significant value in neuroscience and pharmaceutical research due to its role in studying opioid receptor interactions, pain modulation pathways, and the development of novel analgesic agents. It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on neuropharmacology and central nervous system drug discovery.

Application

• Neuroscience Research: Used as a tool compound to investigate the function and binding characteristics of delta (δ) and mu (μ) opioid receptors.
• Analgesic Drug Development: Serves as a key intermediate or reference standard in the design and screening of new, non-addictive pain relief medications.
• Biochemical Assays: Employed in competitive binding assays, receptor autoradiography, and signal transduction studies to understand opioid system biology.
• Peptide Chemistry Studies: Utilized in structure-activity relationship (SAR) studies to elucidate the impact of specific amino acid substitutions on peptide stability and receptor affinity.
• Reference Standard: Acts a high-purity certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.

Basic Information

Product Name	Enkephalinamide, Ala(2,5)-
CAS No.	143791-43-9
Molecular Formula	C28H38N6O7
Molecular Weight	570.64 g/mol
Synonyms	H-Tyr-D-Ala-Gly-Phe-D-Ala-NH2; [D-Ala2, D-Ala5]-Enkephalinamide; [D-Ala2,D-Ala5]-Enkephalin; DADLE Amide; Tyr-D-Ala-Gly-Phe-D-Ala-NH2; δ-Selective Opioid Peptide Analog; (5S)-5-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-oxopentanamide
EINECS	Contact for details

Quality Control

Our Enkephalinamide, Ala(2,5)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, chromatographic data, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (Karl Fischer)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.