Description

Helical Erythrocyte Lysing Peptide is a synthetic, amphipathic α-helical peptide designed for selective membrane disruption. This compound is a critical research tool for the controlled lysis of red blood cells (erythrocytes) in laboratory settings, enabling the isolation of intracellular components or the preparation of hemoglobin-free samples. It is primarily utilized by researchers and quality control laboratories in the biotechnology, pharmaceutical, and clinical diagnostics sectors for applications requiring precise and efficient erythrocyte membrane permeabilization.

Application

• Research Cell Lysis: Selective lysis of erythrocytes for the isolation of leukocytes, platelets, or intracellular parasites in immunological and hematological studies.
• Diagnostic Sample Preparation: Preparation of hemoglobin-free plasma or serum for clinical chemistry assays where hemoglobin interference must be minimized.
• Vaccine Development: Used in processes for the isolation of membrane antigens or in the development of cell-based vaccine platforms.
• Biopharmaceutical Processing: A tool in downstream processing for the gentle release of products from blood-derived cell cultures.
• Basic Membrane Biology: Studying the mechanisms of peptide-induced membrane poration and the biophysics of lipid-peptide interactions.
• Quality Control Testing: Employed in QC labs for testing the robustness of cell-based assays or diagnostic kits that involve blood components.

Basic Information

Product Name	Helical Erythrocyte Lysing Peptide
CAS No.	143780-69-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	HELP Peptide; Erythrocyte Lysis Peptide; Hemolytic Peptide; Membrane Lytic Peptide; Amphipathic Helical Peptide; Synthetic Lytic Peptide; Cell Lysis Peptide 143780-69-2
EINECS	Contact for details

Quality Control

Our Helical Erythrocyte Lysing Peptide is manufactured under controlled conditions to ensure high purity and consistent biological activity. Each batch undergoes rigorous analytical testing, including purity assessment by HPLC and confirmation of structure by mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and performance in a standardized hemolysis assay is provided with every shipment to guarantee it meets stringent research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Hemolytic Activity (EC50)	Specification available upon request
Water Content (KF)	≤ 5.0%
Solubility	Soluble in aqueous buffers, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.