Description

1-(4-Aminophenyl)-3-Methylcarbamyl-4-Methyl-3,4-Dihydro-7,8-Methylenedioxy-5H-2,3-Benzodiazepinehydrochloride is a high-purity, complex benzodiazepine derivative hydrochloride salt, serving as a critical advanced pharmaceutical intermediate. Its value lies in enabling the synthesis of specialized active pharmaceutical ingredients (APIs) with targeted therapeutic effects. This compound is essential for research and development laboratories, process chemists, and manufacturers in the pharmaceutical and life sciences sectors focused on developing novel central nervous system (CNS) agents.

Application

• Pharmaceutical Intermediate: Primary use in the multi-step synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Research & Development: Key building block in medicinal chemistry for designing and testing new drug candidates targeting neurological pathways.
• Process Chemistry: Used in scale-up and optimization studies for the commercial production of specialized therapeutic compounds.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Preclinical Studies: Utilized in the preparation of compounds for pharmacological and toxicological evaluation.

Basic Information

Product Name	1-(4-Aminophenyl)-3-Methylcarbamyl-4-Methyl-3,4-Dihydro-7,8-Methylenedioxy-5H-2,3-Benzodiazepinehydrochloride
CAS No.	143692-48-2
Molecular Formula	C20H21N5O3 · HCl
Molecular Weight	407.87 g/mol (Free base: 371.41 g/mol)
Synonyms	1-(4-Aminophenyl)-3-(methylcarbamoyl)-4-methyl-3,4-dihydro-7,8-(methylenedioxy)-5H-2,3-benzodiazepine hydrochloride; GYKI-52466 dihydrochloride (common research name); 4-Methyl-1-(4-aminophenyl)-3-(N-methylcarbamoyl)-7,8-methylenedioxy-4,5-dihydro-3H-2,3-benzodiazepine hydrochloride; 1-(p-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine HCl; 5H-2,3-Benzodiazepine derivative hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(4-Aminophenyl)-3-Methylcarbamyl-4-Methyl-3,4-Dihydro-7,8-Methylenedioxy-5H-2,3-Benzodiazepinehydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards suitable for pharmaceutical R&D and intermediate use. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.