Description

Cyclo(-D-Phe-His-Trp-Ala-Val-Gly-His-Leu-Leu) is a synthetic cyclic peptide with a specific sequence of nine amino acids. This compound is significant for its role as a potent and selective antagonist of the growth hormone secretagogue receptor (GHSR-1a), making it a critical research tool in endocrinology and metabolic studies. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroendocrinology, obesity, and growth-related disorders. The precise cyclic structure ensures high receptor binding affinity and stability for investigative applications.

Application

• Biomedical Research: Used as a reference standard and active agent in studies investigating the ghrelin receptor (GHSR-1a) signaling pathway.
• Pharmacological Studies: Serves as a key antagonist in vitro and in vivo to block ghrelin-induced effects, aiding in the understanding of appetite regulation and growth hormone release.
• Drug Discovery & Development: A vital tool for screening and validating new therapeutic candidates targeting metabolic disorders, cachexia, and pituitary function.
• Academic & Clinical Research: Employed in laboratory experiments to elucidate the physiological roles of ghrelin in energy homeostasis, stress response, and gastrointestinal motility.
• Biochemical Assay Development: Utilized as a high-purity calibrant or control in developing receptor binding assays and other diagnostic research methods.

Basic Information

Product Name	Cyclo(-D-Phe-His-Trp-Ala-Val-Gly-His-Leu-Leu)
CAS No.	143578-65-8
Molecular Formula	C58H78N16O9
Molecular Weight	1119.34 g/mol
Synonyms	GHSR-1a Antagonist; [D-Lys3]-GHRP-6; Cyclo(His-D-Phe-Ala-Trp-D-Phe-Lys); GHRP-6 Antagonist; Growth Hormone Secretagogue Receptor Antagonist; JMV 2959; Hexarelin Antagonist; Cyclic Peptide Antagonist 143578-65-8
EINECS	Contact for details

Quality Control

Our Cyclo(-D-Phe-His-Trp-Ala-Val-Gly-His-Leu-Leu) is manufactured under strict quality systems suitable for research applications. Each batch undergoes comprehensive analytical testing including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to ensure traceability and meet your specific research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant use and maintain under inert atmosphere if the container is opened frequently. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (Peptide Content)	≥ 80.0%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.