Description

Ifetroban is a potent and selective thromboxane A2 (TXA2) receptor antagonist, a compound of significant interest in pharmaceutical research and development. Its primary value lies in its targeted mechanism of action, which makes it a crucial tool for investigating cardiovascular and renal pathologies associated with TXA2 receptor activity. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those focused on developing novel therapeutics for thrombosis, pulmonary hypertension, and kidney disease.

Application

• Pharmaceutical R&D Intermediate: Serves as a key active pharmaceutical ingredient (API) or advanced intermediate in the synthesis of investigational new drugs.
• Cardiovascular Research: Used in preclinical studies to explore treatments for conditions like thrombosis, atherosclerosis, and myocardial infarction by blocking thromboxane receptors.
• Pulmonary Hypertension Studies: Investigated for its potential to mitigate vascular remodeling and hypertension in pulmonary arterial hypertension (PAH) models.
• Renal Pharmacology: Applied in research targeting kidney diseases, including diabetic nephropathy, due to its effects on renal hemodynamics and fibrosis.
• Biochemical Tool Compound: Utilized in in vitro assays and receptor binding studies to elucidate the TXA2 signaling pathway and screen for new drug candidates.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Ifetroban
CAS No.	143443-90-7
Molecular Formula	C25H28N2O5S
Molecular Weight	468.57 g/mol
Synonyms	BMS-180291; [1S-[1α,2α(Z),3β,4α]]-4-[[7-[[(1,1'-Biphenyl)-4-yl]methoxy]-2,3-dihydro-1H-inden-1-yl]oxy]methyl]-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid; Ifetroban sodium; (+)-Ifetroban; BMS 180291; Ifetroban (BMS-180291); 7-[[(1,1'-Biphenyl)-4-yl]methoxy]-3,4-dihydro-1H-inden-1-yl]oxymethyl]-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
EINECS	Contact for details

Quality Control

Our Ifetroban is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting specifications for assay, related substances, residual solvents, and other critical parameters. We support compliance with cGMP standards for advanced R&D and pre-clinical manufacturing needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.