Description

Alnespirone is a high-purity, non-benzodiazepine anxiolytic agent belonging to the azapirone class of compounds. Its primary value lies in its selective mechanism of action as a serotonin 5-HT1A receptor agonist, making it a compound of significant interest for advanced pharmaceutical research and development. This product is essential for researchers and manufacturers in the global pharmaceutical industry, particularly those focused on developing novel treatments for anxiety disorders, depression, and related central nervous system conditions.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in drug manufacturing.
• Active Pharmaceutical Ingredient (API) R&D: Serves as a key intermediate or the final active substance in preclinical and clinical research for new anxiolytic medications.
• Metabolite and Pharmacokinetic Studies: Employed in studies to understand the drug's absorption, distribution, metabolism, and excretion (ADME) profile.
• Biochemical Research: Used in vitro and in vivo to study the function and signaling pathways of serotonin 5-HT1A receptors.
• Formulation Development: A critical component in developing stable and effective dosage forms, such as tablets or capsules, during the drug development process.

Basic Information

Product Name	Alnespirone
CAS No.	143413-68-7
Molecular Formula	C21H28N4O3
Molecular Weight	384.48 g/mol
Synonyms	Alnespirone; S 20499; (3aα,4α,7α,7aα)-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione; S-20499; 1H-Isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-, (3aα,4α,7α,7aα)-
EINECS	Contact for details

Quality Control

Our Alnespirone CAS NO 143413-68-7 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assay by HPLC, and control of related substances and residual solvents. A Certificate of Analysis (COA) detailing all test results and confirming compliance with specifications is provided with every shipment to ensure traceability and batch-to-batch consistency for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to protect the integrity of the product.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.