Description

L-Tryptophan, L-Leucyl-, Methyl Ester, Hydrochloride (1:1) is a protected dipeptide derivative, specifically the methyl ester hydrochloride salt of the L-Tryptophan-L-Leucine dipeptide. This compound serves as a crucial building block in peptide synthesis, offering enhanced solubility and handling properties for advanced research and development. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers engaged in the development of novel therapeutic peptides and biochemical tools.

Application

• Pharmaceutical Intermediate: A key precursor in the solid-phase and solution-phase synthesis of complex peptide-based drug candidates and APIs.
• Biochemical Research: Used as a standardized reagent for studying peptide structure-activity relationships (SAR) and enzyme-substrate interactions.
• Protecting Group Strategy: The methyl ester moiety provides a temporary carboxyl protection, which is cleavable under specific conditions during multi-step peptide assembly.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in peptide analysis laboratories.
• Cosmeceutical Peptide Synthesis: Potential use as a starting material for synthesizing bioactive peptides used in advanced skincare formulations.

Basic Information

Product Name	L-Tryptophan, L-Leucyl-, Methyl Ester, Hydrochloride (1:1)
CAS No.	143413-36-9
Molecular Formula	C19H26N3O3 · HCl
Molecular Weight	380.89 g/mol (Free base: 344.43 g/mol)
Synonyms	L-Leucyl-L-tryptophan methyl ester hydrochloride; H-Leu-Trp-OMe · HCl; Methyl L-leucyl-L-tryptophanate hydrochloride; Leu-Trp-OMe hydrochloride; Tryptophan, L-leucyl-, methyl ester, hydrochloride; N-(N-L-Leucyl-L-tryptophyl) methyl ester hydrochloride; L-Tryptophan, N-L-leucyl-, methyl ester, hydrochloride (1:1); (S)-Methyl 2-((S)-2-amino-4-methylpentanamido)-3-(1H-indol-3-yl)propanoate hydrochloride
EINECS	Contact for details

Quality Control

Our L-Tryptophan, L-Leucyl-, Methyl Ester, Hydrochloride (1:1) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification, to ensure it meets the stringent requirements for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency for critical R&D and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.