Description

Dynorphin A (1-13), Asn(2)-Trp(4)- is a synthetic peptide fragment of the endogenous opioid neuropeptide Dynorphin A, specifically modified at the second and fourth amino acid positions. This compound is a critical research tool for investigating the κ-opioid receptor (KOR) system, pain pathways, and neuropsychiatric disorders. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuroscience and analgesic drug discovery.

Application

• Neuroscience Research: As a selective κ-opioid receptor (KOR) agonist for studying receptor binding, signal transduction, and behavioral effects.
• Pain Mechanism Studies: Investigation of endogenous pain modulation pathways and the development of novel, non-addictive analgesic targets.
• Psychiatric Disorder Models: Research into the role of the dynorphin/KOR system in stress, depression, addiction, and related neuropsychiatric conditions.
• Biochemical Assay Development: Used as a reference standard or active agent in cell-based assays, receptor binding studies, and functional screens.
• Peptide Chemistry & Pharmacology: Serving as a key intermediate or analog in structure-activity relationship (SAR) studies for peptide-based therapeutics.

Basic Information

Product Name	Dynorphin A (1-13), Asn(2)-Trp(4)-
CAS No.	143407-24-3
Molecular Formula	C78H111N21O18
Molecular Weight	1606.9 g/mol
Synonyms	Dynorphin A (1-13) amide, [Asn2, Trp4]-; [Asn2,Trp4]-Dynorphin A (1-13); H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH (with Asn2, Trp4 substitution); Dynorphin A 1-13 analog; κ-opioid receptor peptide agonist; [Asn2,Trp4]Dynorphin A(1-13)NH2; YGGFLRRIRPKLK-NH2 (modified sequence)
EINECS	Contact for details

Quality Control

Every batch of Dynorphin A (1-13), Asn(2)-Trp(4)- is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment aligns with standards expected for research-grade bioactive peptides. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), molecular weight confirmation (MS), and peptide content is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.