Description

4(1H)-Pyrimidinone, 5-Fluoro-2-((2-Methylphenyl)Methyl)- is a specialized fluorinated pyrimidinone derivative, a key building block in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique structure enables precise molecular modifications. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries seeking to innovate and scale new products.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic research.
• Agrochemical Synthesis: Serves as a key building block for developing new-generation herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Fine Chemical Production: Used in the manufacture of complex specialty chemicals, dyes, and advanced materials requiring fluorinated heterocyclic cores.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies, structure-activity relationship (SAR) exploration, and novel reaction pathway development.
• Process Chemistry & Scale-Up: Integral to route scouting and optimization for the commercial-scale production of target molecules containing the fluoropyrimidinone moiety.

Basic Information

Product Name	4(1H)-Pyrimidinone, 5-Fluoro-2-((2-Methylphenyl)Methyl)-
CAS No.	143328-93-2
Molecular Formula	C₁₂H₁₁FN₂O
Molecular Weight	218.23 g/mol
Synonyms	5-Fluoro-2-(o-tolylmethyl)pyrimidin-4(1H)-one; 5-Fluoro-2-((2-methylbenzyl))-4(1H)-pyrimidinone; 2-((2-Methylphenyl)methyl)-5-fluoropyrimidin-4(1H)-one; 5-Fluoro-2-(2-methylbenzyl)-1H-pyrimidin-4-one; 143328-93-2; Fluorinated Pyrimidinone Derivative; o-Methylbenzyl Fluoropyrimidinone
EINECS	Contact for details

Quality Control

Our 4(1H)-Pyrimidinone, 5-Fluoro-2-((2-Methylphenyl)Methyl)- is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or opaque to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.