Description

α-Conotoxin Sii CAS NO 143294-31-9 is a selective and potent peptide neurotoxin derived from the venom of marine cone snails. This compound is a valuable research tool for studying and characterizing specific subtypes of nicotinic acetylcholine receptors (nAChRs) in the central and peripheral nervous systems. It is primarily utilized by pharmaceutical researchers, neuroscientists, and academic institutions engaged in neurological research, drug discovery, and the development of novel therapeutic agents.

Application

• Neuroscience Research: As a selective antagonist for neuronal nAChR subtypes, it is used to investigate receptor function, distribution, and role in synaptic transmission.
• Drug Discovery & Development: Serves as a critical pharmacological tool for screening and validating new compounds targeting nAChRs for conditions like pain, addiction, and neurodegenerative diseases.
• Physiological Studies: Employed in electrophysiology and patch-clamp experiments to block specific receptor currents and study neuronal circuitry.
• Biochemical Assays: Used in binding assays and other in vitro studies to quantify receptor expression and ligand interactions.
• Academic & Institutional Research: A key reagent for universities and research institutes focusing on neuropharmacology and molecular biology.

Basic Information

Product Name	α-Conotoxin Sii
CAS No.	143294-31-9
Molecular Formula	C58H86N18O18S5
Molecular Weight	1419.7 g/mol
Synonyms	α-Conotoxin SII; α-Conotoxin SII; Conotoxin SII; SII Conotoxin; α-SII; Alpha Conotoxin from Conus striatus; α-Conotoxin SI; Nicotinic Acetylcholine Receptor Antagonist (α3β2 subtype)
EINECS	Contact for details

Quality Control

Our α-Conotoxin Sii is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and biological activity. We adhere to high-purity peptide standards, and specifications can be provided to meet specific research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Biological Activity	Specified per batch (IC50 for α3β2 nAChR)
Solubility	Soluble in aqueous buffers or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.