Description

4(S)-(3,4-Dihydro-2,4-Dioxo-5-Methyl-1(2H)-Pyrimidinyl)Tetrahydro-2(S)-Furanmethanol CAS NO 143191-83-7 is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. Its value lies in its role as a key building block for the production of nucleoside analogs and other active pharmaceutical ingredients (APIs). This compound is essential for research institutions and manufacturers in the pharmaceutical and biotechnology sectors requiring precise stereochemistry for drug development.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Antiviral Drug Development: Serves as a key precursor for the research and production of reverse transcriptase inhibitors and other antiviral compounds.
• Biochemical Research: Used as a standard or reagent in enzymatic studies and metabolic pathway research involving modified nucleosides.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for complex, stereospecific molecules in GMP environments.
• Contract Manufacturing (CMO): Supplied to CMOs for the production of clinical trial materials and commercial APIs under strict quality agreements.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry projects and the development of new synthetic methodologies.

Basic Information

Product Name	4(S)-(3,4-Dihydro-2,4-Dioxo-5-Methyl-1(2H)-Pyrimidinyl)Tetrahydro-2(S)-Furanmethanol
CAS No.	143191-83-7
Molecular Formula	C10H14N2O5
Molecular Weight	242.23 g/mol
Synonyms	(2S,4S)-4-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran; 1-(2S,4S)-4-(Hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; 5-Methyl-1-[(2S,4S)-4-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione; L-Nucleoside Intermediate; Chiral Dihydrothymidine Derivative; (2S,4S)-Dihydrothymidine Derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 4(S)-(3,4-Dihydro-2,4-Dioxo-5-Methyl-1(2H)-Pyrimidinyl)Tetrahydro-2(S)-Furanmethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (2S,4S isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.