Description

1-Cyclopropyl-8-Ethoxy-6,7-Difluoro-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound serves as a critical building block in the synthesis of novel fluoroquinolone antibiotics, a class known for their broad-spectrum antibacterial activity. It is essential for pharmaceutical R&D laboratories, process development chemists, and manufacturers engaged in the production of next-generation antimicrobial agents. The compound's precise structure allows for targeted modifications to enhance drug efficacy and safety profiles.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor in the manufacture of advanced fluoroquinolone antibiotic APIs (Active Pharmaceutical Ingredients).
• Antibacterial Drug Development: Core scaffold for research into new antibacterial agents targeting resistant bacterial strains.
• Chemical Synthesis: Used in organic synthesis for constructing complex quinoline-based molecular architectures.
• Process Chemistry & Scale-Up: Critical for process optimization and pilot-scale production runs in cGMP environments.
• Reference Standard: Serves as an analytical standard for quality control and regulatory submissions in pharmaceutical manufacturing.
• Academic & Institutional Research: Utilized in medicinal chemistry programs to study structure-activity relationships (SAR) of quinolone derivatives.

Basic Information

Product Name	1-Cyclopropyl-8-Ethoxy-6,7-Difluoro-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid
CAS No.	143158-55-8
Molecular Formula	C₁₅H₁₃F₂NO₄
Molecular Weight	309.27 g/mol
Synonyms	8-Ethoxy-6,7-difluoro-1-cyclopropyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6,7-difluoro-8-ethoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid; 1-Cyclopropyl-8-ethoxy-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid; Quinolone Carboxylic Acid Derivative; Fluoroquinolone Intermediate; 143158-55-8; 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-ethoxy-4-oxo-3-quinolinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our 1-Cyclopropyl-8-Ethoxy-6,7-Difluoro-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment aligns with ICH guidelines and supports our customers' needs for regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.