Description

2',2'-Difluoro-2'-Deoxyuridine 3',5'-Dibenzoate is a key fluorinated nucleoside derivative, specifically a protected intermediate of the important antiviral and anticancer agent Gemcitabine. This high-purity chemical building block is critical for ensuring the quality and efficacy of the final active pharmaceutical ingredient (API). It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of nucleoside-based therapeutics.

Application

• Pharmaceutical Intermediate: A crucial protected precursor in the multi-step synthesis of Gemcitabine (dFdC) hydrochloride, a frontline chemotherapy agent.
• Antiviral & Anticancer Research: Serves as a vital scaffold for medicinal chemists developing novel nucleoside analogs with modified sugar moieties for targeted activity.
• Process Chemistry & Scale-Up: Used in optimizing and scaling manufacturing routes for Gemcitabine API, where consistent quality of intermediates is paramount.
• Biochemical Tool: Can be utilized in studies investigating the structure-activity relationships (SAR) of fluorinated nucleosides and their metabolism.
• Reference Standard: Employed as a high-purity analytical standard for quality control during Gemcitabine production and regulatory submissions.

Basic Information

Product Name	2',2'-Difluoro-2'-Deoxyuridine 3',5'-Dibenzoate
CAS No.	143157-27-1
Molecular Formula	C24H20F2N2O7
Molecular Weight	486.42 g/mol
Synonyms	2'-Deoxy-2',2'-difluorouridine 3',5'-dibenzoate; 3',5'-Di-O-benzoyl-2'-deoxy-2',2'-difluorouridine; Gemcitabine Intermediate; dFdU 3',5'-Dibenzoate; 2'-Deoxy-2',2'-difluorouridine dibenzoate; LY188011 Dibenzoate; NSC 613327 Dibenzoate; 2',2'-Difluoro-2'-deoxyuridine dibenzoate
EINECS	Contact for details

Quality Control

Our 2',2'-Difluoro-2'-Deoxyuridine 3',5'-Dibenzoate is manufactured under strict quality management systems suitable for pharmaceutical intermediate applications. Each batch is subjected to rigorous analytical testing including HPLC, NMR, and MS to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and support your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged manipulations to ensure stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.