Description

Fmoc-Cys(Tbuthio)-Opfp is a specialized, activated ester derivative of the amino acid cysteine, protected with the tert-butylthio (Tbuthio) group on the side chain and the fluorenylmethyloxycarbonyl (Fmoc) group on the amine. This compound is a critical building block in solid-phase peptide synthesis (SPPS), designed for the efficient and controlled incorporation of cysteine residues while protecting its reactive thiol functionality. It is essential for researchers and manufacturers in pharmaceutical development, bioconjugation, and peptide therapeutics, where precise sequence control and side-chain protection are paramount for producing high-purity, biologically active peptides.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the automated, stepwise assembly of peptide chains, specifically for introducing protected cysteine residues.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation Chemistry: Serves as a precursor for creating peptide-protein or peptide-small molecule conjugates, useful in drug delivery systems and diagnostic probes.
• Production of Disulfide-Rich Peptides: Enables the synthesis of complex peptides containing disulfide bridges, which are crucial for the structural stability and biological activity of many therapeutic peptides.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Institutional Research: A fundamental tool in biochemistry and molecular biology laboratories for studying protein structure-function relationships.

Basic Information

Product Name	Fmoc-Cys(Tbuthio)-Opfp
CAS No.	143038-41-9
Molecular Formula	C29H24F5NO4S2
Molecular Weight	609.63 g/mol
Synonyms	Fmoc-Cys(StBu)-OPfp; Fmoc-S-tert-butylthio-L-cysteine pentafluorophenyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-(tert-butylthio)-L-cysteine 2,3,4,5,6-pentafluorophenyl ester; Fmoc-Cys(StBu)-OPfp ester; Fmoc-Cysteine(StBu)-OPfp; Nα-Fmoc-S-tert-butylthio-L-cysteine pentafluorophenyl ester; Fmoc-L-Cys(StBu)-OPfp
EINECS	Contact for details

Quality Control

Our Fmoc-Cys(Tbuthio)-Opfp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool place. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.