Description

Dl-Valine, 2-[(2-Amino-1,6-Dihydro-6-Oxo-9H-Purin-9-Yl)Methoxy]Ethyl Ester, Monohydrochloride is a chemically modified nucleoside derivative, specifically a valine ester prodrug of a guanine analog. This compound is of significant interest in pharmaceutical research and development due to its potential as a bioactive precursor or intermediate. It is primarily sought by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the synthesis of novel antiviral or anticancer agents.

Application

• Pharmaceutical Intermediate: Key building block in the research and synthesis of nucleoside-based prodrugs for therapeutic applications.
• Antiviral Agent Research: Serves as a critical precursor in the development of novel antiviral compounds, particularly those targeting viral polymerases.
• Oncology Research: Investigated as a potential intermediate for antimetabolite drugs used in cancer chemotherapy.
• Biochemical Research: Used in studies exploring nucleotide metabolism, enzyme inhibition, and cell signaling pathways.
• Fine Chemical Synthesis: Employed in custom synthesis and process development for high-value, complex organic molecules.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	Dl-Valine, 2-[(2-Amino-1,6-Dihydro-6-Oxo-9H-Purin-9-Yl)Methoxy]Ethyl Ester, Monohydrochloride
CAS No.	142963-71-1
Molecular Formula	C14H21N7O4 • HCl
Molecular Weight	387.82 g/mol (free base) / 424.28 g/mol (HCl salt)
Synonyms	9-[(2-(DL-Valyloxy)ethoxy)methyl]guanine monohydrochloride; 2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl DL-valinate hydrochloride; Valacyclovir related compound; Acyclovir valine ester hydrochloride; Guanine, 9-[2-[(2-methyl-1-oxopropoxy)ethoxy]methyl]-, monohydrochloride; DL-Valine ester of 9-[(2-hydroxyethoxy)methyl]guanine hydrochloride; VACV impurity standard
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS). We ensure compliance with relevant ICH guidelines for impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the assay, related substances, residual solvents, and other critical parameters. Custom synthesis and specific grade requirements (e.g., research grade, GMP-grade) can be discussed.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions. Keep container tightly sealed when not in use to prevent absorption of moisture from the atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.