Description

Polyphemusin Ii, Tyr(5,12)-Lys(7)- is a synthetic, biologically active peptide analog derived from the natural antimicrobial peptide Polyphemusin I. This compound is significant for its potent antimicrobial and antiviral properties, particularly against enveloped viruses, making it a valuable research tool. It is primarily needed by researchers and developers in the pharmaceutical and biotechnology sectors for studying host defense peptides, developing novel therapeutics, and exploring mechanisms of microbial membrane disruption.

Application

• Antimicrobial Research: Investigation of mechanisms of action against bacteria, fungi, and other pathogens.
• Antiviral Agent Development: Study of activity against enveloped viruses such as HIV and HSV.
• Peptide Chemistry & Drug Discovery: Serves as a key intermediate or reference standard in the design of novel peptide-based therapeutics.
• Membrane Biophysics: Used in research to understand peptide-lipid interactions and membrane permeabilization.
• Immunology Studies: Exploration of the role of host defense peptides in innate immunity.
• Biochemical Assay Standard: Acts as a control or standard in bioassays measuring antimicrobial or hemolytic activity.

Basic Information

Product Name	Polyphemusin Ii, Tyr(5,12)-Lys(7)-
CAS No.	142960-16-5
Molecular Formula	C95H147N31O25S2
Molecular Weight	~2188.5 g/mol
Synonyms	Tachyplesin I analog; [Tyr5,12, Lys7]-Polyphemusin II; Polyphemusin II (5-12,7)-substituted analog; Antimicrobial peptide analog; Host defense peptide; RP 71955; Tachyplesin-derived peptide; CAS 142960-16-5
EINECS	Contact for details

Quality Control

Our Polyphemusin Ii, Tyr(5,12)-Lys(7)- is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters. We adhere to rigorous quality testing protocols, and specifications can be aligned with customer requirements for advanced research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.