Description

Leiurotoxin I CAS NO 142948-19-4 is a highly specific and potent peptide toxin derived from scorpion venom. This compound is of significant value in neuroscience and pharmacological research due to its selective inhibition of calcium-activated potassium channels. It is primarily utilized by research institutions and pharmaceutical companies for studying ion channel function, neurological disorders, and as a template for novel therapeutic agent development.

Application

• Neuroscience Research: As a critical tool for studying the structure, function, and modulation of calcium-activated potassium (SK) channels.
• Pharmacological Studies: Used in high-throughput screening and electrophysiology assays to identify and characterize new channel modulators.
• Drug Discovery: Serves as a molecular scaffold or lead compound for developing new treatments targeting neurological and cardiovascular conditions.
• Biochemical Reagent: Employed in protein-protein interaction studies and the development of specialized diagnostic assays.
• Academic Research: Essential for fundamental biological research in university and institutional laboratories focused on cellular excitability and signal transduction.

Basic Information

Product Name	Leiurotoxin I
CAS No.	142948-19-4
Molecular Formula	C185H284N52O55S7
Molecular Weight	~4235.9 g/mol
Synonyms	Scyllatoxin; Leiurotoxin 1; Charybdotoxin-like peptide from Leiurus quinquestriatus hebraeus; Toxin Scy; Potassium channel toxin α-KTx 6.2; Iberiotoxin homolog; BLTX; Apamin-like peptide
EINECS	Contact for details

Quality Control

Our Leiurotoxin I is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and high biological activity. Each lot is subjected to comprehensive analytical testing, including HPLC for purity assessment, mass spectrometry for identity confirmation, and functional bioassays to verify potency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under anhydrous conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Biological Activity (IC50)	Specified per batch on COA
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in water or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.