Description

5,5-Dimethyl-L-Norleucine is a non-proteinogenic, sterically hindered amino acid derivative of significant interest in advanced chemical synthesis. Its unique structure, featuring geminal dimethyl groups on the gamma carbon, makes it a valuable chiral building block for modifying peptide backbones and creating novel molecular architectures. This compound is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for applications such as peptide drug development, proteomics research, and the synthesis of specialized biochemical tools.

Application

• Pharmaceutical Intermediates: Serves as a key chiral synthon in the research and development of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).
• Peptidomimetics & Drug Design: Used to introduce conformational constraints and enhance metabolic stability in peptide backbones during the design of peptidomimetic compounds.
• Biochemical Research: Employed as a specialized amino acid analog in proteomics studies, enzyme substrate investigations, and metabolic pathway analysis.
• Ligand Synthesis: Acts as a precursor for synthesizing chiral ligands used in asymmetric catalysis and metal complexation.
• Academic & Industrial R&D: A valuable tool for chemists in academic institutions and corporate R&D labs exploring structure-activity relationships (SAR) and new chemical entities.

Basic Information

Product Name	5,5-Dimethyl-L-Norleucine
CAS No.	142886-13-3
Molecular Formula	C8H17NO2
Molecular Weight	159.23 g/mol
Synonyms	L-2-Amino-5,5-dimethylhexanoic acid; (S)-2-Amino-5,5-dimethylhexanoic acid; (S)-5,5-Dimethylnorleucine; 5,5-Dimethyl-L-2-aminocaproic acid; D,L-5,5-Dimethylnorleucine (mixture); 5,5-Dimethylnorleucine; gamma,γ-Dimethyl-L-norleucine
EINECS	Contact for details

Quality Control

Our 5,5-Dimethyl-L-Norleucine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We employ advanced analytical techniques, including HPLC and chiral analysis, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing specific test results is provided with each shipment to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.