Description

5,5-Dimethyl-D-Norleucine is a non-proteinogenic, synthetic D-amino acid derivative characterized by its unique gem-dimethyl substitution on the gamma carbon of the side chain. This structural feature imparts significant conformational rigidity and metabolic stability, making it a valuable chiral building block for advanced pharmaceutical research and development. It is primarily utilized by medicinal chemists and researchers in the pharmaceutical, biotechnology, and fine chemical synthesis sectors for constructing novel peptide-based therapeutics, enzyme inhibitors, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel peptide drugs and protease inhibitors.
• Medicinal Chemistry Research: Used to introduce conformational constraints into peptide backbones to enhance binding affinity and metabolic stability.
• Bioconjugation & Probe Development: Serves as a modified amino acid for creating labeled peptides and biochemical probes.
• Asymmetric Synthesis: Employed as a building block in the synthesis of complex natural products and chiral compounds.
• Peptidomimetics: Integral for designing and synthesizing peptidomimetic molecules that mimic natural peptides.

Basic Information

Product Name	5,5-Dimethyl-D-Norleucine
CAS No.	142886-12-2
Molecular Formula	C8H17NO2
Molecular Weight	159.23 g/mol
Synonyms	D-2-Amino-5,5-dimethylhexanoic acid; (R)-2-Amino-5,5-dimethylhexanoic acid; D-5,5-Dimethylnorleucine; D-5,5-Dimethyl-2-aminocaproic acid; (R)-5,5-Dimethylnorleucine; D-gamma,γ-Dimethylnorleucine; D-Homovaline (deprecated); D-2-Amino-5,5-dimethylcaproic acid
EINECS	Contact for details

Quality Control

Our 5,5-Dimethyl-D-Norleucine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.