Description

5,5-Dimethylnorleucine is a non-proteinogenic amino acid derivative characterized by its unique branched-chain structure. This compound serves as a critical building block in the synthesis of complex peptides and pharmaceutical intermediates, offering enhanced metabolic stability and structural diversity. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for metabolic and neurological targets.
• Peptide Chemistry: Used to incorporate sterically hindered, non-natural amino acids into peptide chains to modulate bioactivity, stability, and pharmacokinetic properties.
• Proteomics Research: Employed as a stable isotope-labeled analog or a metabolic probe in biochemical and proteomic studies to investigate protein function and interactions.
• Ligand Development: Serves as a scaffold for developing enzyme inhibitors or receptor ligands in medicinal chemistry campaigns.
• Bioconjugation: Utilized in the design of linkers and spacers for antibody-drug conjugates (ADCs) and other bioconjugate therapeutics.
• Material Science: Acts as a monomer or modifier in the synthesis of specialized polymers and biomaterials with tailored properties.

Basic Information

Product Name	5,5-Dimethylnorleucine
CAS No.	142886-10-0
Molecular Formula	C8H17NO2
Molecular Weight	159.23 g/mol
Synonyms	2-Amino-5,5-dimethylhexanoic acid; 5,5-Dimethyl-L-norleucine; (S)-2-Amino-5,5-dimethylhexanoic acid; D,L-5,5-Dimethylnorleucine; 5,5-Dimethylnorleucine; Norleucine, 5,5-dimethyl-; 5,5-Dimethyl-2-aminocaproic acid
EINECS	Contact for details

Quality Control

Our 5,5-Dimethylnorleucine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets stringent specifications for research and cGMP-grade applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with relevant standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (enantiomeric excess)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.