Description

H-Met-Pro-Oh CAS NO 142702-34-9 is a high-purity, protected dipeptide building block, specifically L-Methionyl-L-Proline, where the C-terminal carboxylic acid is protected as a tert-butyl ester. This compound is a critical intermediate for the synthesis of complex peptides and peptidomimetics, offering precise control over molecular structure. It is primarily utilized by pharmaceutical R&D departments, biotechnology firms, and fine chemical manufacturers engaged in the development of therapeutic peptides, protease inhibitors, and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Key building block in the solid-phase and solution-phase synthesis of therapeutic peptides targeting metabolic and cardiovascular diseases.
• Protease Inhibitor Development: Serves as a core structural motif in the research and production of inhibitors for enzymes like prolyl oligopeptidase.
• Peptidomimetic Research: Used to create stable, bioavailable analogs of natural peptide hormones for drug discovery programs.
• Bioconjugation & Labeling: The reactive amine and protected carboxyl groups allow for site-specific modifications and linker attachment.
• Academic & Contract Research: Essential reagent for universities and CROs studying peptide structure-activity relationships (SAR) and folding.
• Precursor for API Synthesis: An advanced intermediate in multi-step synthetic routes for Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	H-Met-Pro-Oh CAS NO 142702-34-9
CAS No.	142702-34-9
Molecular Formula	C14H26N2O4S
Molecular Weight	318.43 g/mol
Synonyms	L-Methionyl-L-proline tert-butyl ester; H-Met-Pro-OtBu; Methionine-Proline tert-butyl ester; N-(Methoxycarbonyl)-L-methionyl-L-proline tert-butyl ester; Boc-Met-Pro-OtBu (common precursor); Fmoc-Met-Pro-OtBu (common precursor); (S)-2-((S)-2-(tert-Butoxy)-1-oxo-4-(methylthio)butyl)pyrrolidine-1-carboxylic acid; Protected Met-Pro dipeptide
EINECS	Contact for details

Quality Control

Our H-Met-Pro-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and NMR for structural confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopeial standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions (e.g., nitrogen or argon atmosphere) when opening to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms to structure
Identification (IR)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH limits
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.